Due to the application of heat exchange equipment such as converters in various industries, improving heat transfer in this equipment is very important. Various methods are used to improve heat transfer. In this paper, the effect of nanofluid and quadruple barrier type barrier on heat transfer coefficient has been investigated numerically with Ansis Fluent software. The nanofluidused is considered as a homogeneous fluid and the effect of increasing the nanoparticle is applied as an effect on the properties of the nanofluid. The heat transfer coefficient for pure and nanofluid water and barriers in different states was obtained and the amount of heat transfer improvement was obtained. The flow inside the pipe was turbulent and The Reynolds number was considered in the range of 5600 to 12000. Simulation for simple tube mode with pure water, simple tube with nanofluid with volume fraction of 0.5%, tube with barrier with 3, 4 and 5 mm offerings with nanofluid with volume fraction of 0.5% The results showed that with the introduction of nanoparticles, the heat transfer coefficient increased by 52.87%. It also showed that the highest value of Nusseltnumber was obtained in 4 mm width of torsional strips. In this case, the increase in Nusselt number compared to the unobstructed mode in Reynolds 12000 increased by 64.58%. The value of the coefficient of friction was evaluated to determine the pressure drop. At the 3 mm width of the barrier, the maximum coefficient of friction was obtained. In this case, the coefficient of friction increased by 14.26% compared to the unobstructed mode.