In the present study, energy and exergy analysis of a hybrid system including concentrating photovoltaic thermal module, organic Rankine cycle, single-effect water / lithium-bromide adsorption cooling and membrane distillation desalination at transient conditions is performed. The combined energy and exergy analyzes of the system were performed by a computer program written in EES software. The results showed that the annual electrical power generated by concentrating photovoltaic thermal modules and organic Rankine cycle are 81.74 MWh and 13.84 MWh, respectively. In addition, the cooling capacity of the refrigeration cycle is 32.91 MWh and the membrane distillation desalination plant produces fresh water at a rate of 0.3025 kg/s.m². The degraded exergy of the concentrating photovoltaic system and organic Rankin cycle is 35.36 MWh and 11.43 MWh, respectively. The exergy efficiency of the absorption cooling cycle is 17.57%. Also, in membrane distillation desalination, the total degradation rate is 6.32 MWh. In addition, the obtained results prdedicts thermal efficiency and exergy efficiency of 75% and 72.93% for the combined system, respectively.